IDENTIFICATION OF NOVEL CHEMICAL SCAFFOLDS THAT INHIBIT THE GROWTH OF MYCOBACTERIUM TUBERCULOSIS IN MACROPHAGES

Identification of Novel Chemical Scaffolds that Inhibit the Growth of Mycobacterium tuberculosis in Macrophages

Mycobacterium tuberculosis is an important global pathogen for which new drugs are urgently required.The ability of the organism to survive and multiply within macrophages may contribute to the lengthy treatment Deck Mount Faucets regimen with multiple drugs that are required to cure the infection.We screened the MyriaScreen II diversity library of

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Constraints on superoxide mediated formation of manganese oxides

Manganese (Mn) oxides are among the most reactive sorbents and oxidants within the environment, where they play a central role in the cycling of nutrients, metals, and carbon.Recent discoveries have identified superoxide (O2-) (both of biogenic and abiogenic origin) as an effective oxidant of Mn(II) leading to the formation of Mn oxides.Here we exa

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Factors associated with the intention of Syrian adult population to accept COVID19 vaccination: a cross-sectional study

Abstract Background and objectives With global efforts to develop and deliver a COVID-19 vaccine rapidly, vaccine hesitancy stands as a barrier to these efforts.We aimed to estimate the proportion of Syrian adult population intending to be vaccinated against COVID-19 and, principally, to assess the demographic and attitudinal factors associated wit

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Evidence for long-term association of virion-delivered HBV core protein with cccDNA independently of viral protein production

Background & Aims: HBV persists in the nucleus of infected hepatocytes as a covalently closed circular DNA (cccDNA) episome that constitutes the template for viral RNA and protein synthesis.Both HBx and HBc (core) viral proteins associate with cccDNA but, while HBx is required for viral transcription, the role of HBc is still unclear.The aim of

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